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The Roman Catholic Church mourns the death of the Pope in Rome. Until the College of Cardinals selects a new Bishop, Camerlengo Patrick McKenna (Ewan McGregor) assumes day-to-day control of Vatican City. Reporters, nuns, priests, and other faithful all crowd into Saint Peter's Square, waiting for the white smoke from the conclave. The Vatican summons Professor Robert Langdon (Tom Hanks) and Vittoria Vetra (Ayelet Zurer) from CERN to help them solve the Illuminati's threat, save the four preferiti, and find the hidden bomb. Langdon listens to the Illuminati message and deduces that the four cardinals will die at the four altars of the Path of Illumination. However, no one knows where these altars are located, but they are all somewhere in Rome. Langdon demands access to the Vatican Secret Archives to see the original copy of Galileo Galilei's banned book, as it contains clues to the Illuminati plot. Eventually, he is able to convince the camerlengo to grant him access. Using the clue from this book, Langdon, Vetra, and Inspector General Ernesto Olivetti (Pierfrancesco Favino) of the Vatican police start their quest across Rome.